Komodo is a great cross-platform IDE. But I've noticed that as file size increases, Komodo's performance slows to a crawl, becoming practically unusable once files hit 2.5k lines or so.
I opened a thread about it on ActiveState's community site (which happens to be running Drupal!). It seems this is a known issue on OSX and they're looking into it.
If you want to subscribe to the bug itself, you can find it here.